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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD3
All Species:
50.91
Human Site:
T412
Identified Species:
93.33
UniProt:
P84022
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P84022
NP_001138574.1
425
48081
T412
Q
W
L
D
K
V
L
T
Q
M
G
S
P
S
I
Chimpanzee
Pan troglodytes
XP_001159972
710
77879
T697
Q
W
L
D
K
V
L
T
Q
M
G
S
P
S
I
Rhesus Macaque
Macaca mulatta
XP_001111262
425
48034
T412
Q
W
L
D
K
V
L
T
Q
M
G
S
P
S
I
Dog
Lupus familis
XP_866258
457
51167
T444
Q
W
L
D
K
V
L
T
Q
M
G
S
P
S
V
Cat
Felis silvestris
Mouse
Mus musculus
Q62432
467
52248
T454
Q
W
L
D
K
V
L
T
Q
M
G
S
P
S
V
Rat
Rattus norvegicus
O70436
467
52221
T454
Q
W
L
D
K
V
L
T
Q
M
G
S
P
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505221
437
48895
T424
Q
W
L
D
K
V
L
T
Q
M
G
S
P
S
V
Chicken
Gallus gallus
P84023
426
48233
T413
Q
W
L
D
K
V
L
T
Q
M
G
S
P
S
I
Frog
Xenopus laevis
NP_001079320
425
48022
T412
Q
W
L
D
K
V
L
T
Q
M
G
S
P
S
I
Zebra Danio
Brachydanio rerio
Q9I9P9
468
52435
T455
Q
W
L
D
K
V
L
T
Q
M
G
S
P
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
T442
Q
W
L
D
K
V
L
T
Q
M
G
S
P
H
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q02330
418
47907
S405
A
W
L
D
R
V
L
S
T
M
G
P
T
P
R
Sea Urchin
Strong. purpuratus
NP_001075435
427
48320
T414
Q
W
L
D
R
V
L
T
Q
M
V
P
P
D
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
59.8
99.7
85.3
N.A.
83.9
83.7
N.A.
89.9
98.8
95.7
83.3
N.A.
60
N.A.
49.6
78.6
Protein Similarity:
100
59.8
99.7
89.5
N.A.
88
88
N.A.
94.2
99.5
98.8
87.1
N.A.
73.1
N.A.
64.2
88.7
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
93.3
100
100
93.3
N.A.
86.6
N.A.
46.6
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
86.6
N.A.
60
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
100
0
0
0
0
0
0
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
93
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
39
% I
% Lys:
0
0
0
0
85
0
0
0
0
0
0
0
0
0
8
% K
% Leu:
0
0
100
0
0
0
100
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
100
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
16
93
8
0
% P
% Gln:
93
0
0
0
0
0
0
0
93
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
16
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
0
0
0
0
0
0
8
0
0
0
85
0
77
0
% S
% Thr:
0
0
0
0
0
0
0
93
8
0
0
0
8
0
0
% T
% Val:
0
0
0
0
0
100
0
0
0
0
8
0
0
0
39
% V
% Trp:
0
100
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _